Here is what I could find searching
The Grand History of the Realms. Note that the Wailing death (1372) is indeed canon and serves as the basis for the game's official campaign, but none of the events in the game or expansions are canon.
87 DR Year of the Hoar Frost
Eigersstor (Neverwinter) is founded.
457 DR Year of the Unfurled Flag
The mages Aganazzar, Ilyykur, Presper, and Grimwald found the School of Wizardry in Neverwinter and begin taking on apprentices from around Faerûn.
1081 DR Year of the Disastrous Bauble
Another one of the Four Founders of the Covenant dies when the Red Wizards of Thay kill Aganazzar in their assault on the School of Wizardry in Neverwinter. By year’s end, the two groups are engaged in a titanic wizardwar.
1301 DR Year of the Trumpet
A mercenary army sponsored by merchant interests in Waterdeep and Neverwinter rides against orc-ridden Illusk
1302 DR Year of the Broken Helm
Illusk is retaken and rebuilt with aid from Neverwinter, then renamed Luskan.
1310 DR Year of Storms
A vast pirate fleet from the Nelanther Isles attacks and conquers Luskan. The leaders of the pirate fleet (Taerl, Baram, Kurth, Suljack, and Rethnor) declare themselves the new rulers of the city, each taking the title of High Captain.
1311 DR Year of the Fist
The mage Arklem Greeth comes to Luskan and bypasses the ancient magic wards that Laeral Silverhand placed around the Host Tower. He forms the Brotherhood of the Arcane with the aid of the Old Ones powerful liches who were once members of the legendary Grand Cabal of Illusk. Arklem names himself Archmage Arcane of the Brotherhood.
1354 DR Year of the Bow
The High Captains of Luskan come fully under the sway of the Arcane Brotherhood, cementing its secret rule over the city.
1372 DR Year of Wild Magic Tarsakh 30: Citizens of Neverwinter begin falling ill from a plague later known as the Wailing Death. Within a few tendays, most inhabitants of the city are dead or dying.
Some very interesting info...from the FR Wiki
http://forgottenrealms.wikia.com/wiki/
-Neverwinter is often referred to as The City of Skilled Hands or the Jewel of the North.
-Neverwinter's master-craftsmen make lamps of multi-coloured glass, precision water clocks and exquisite jewellery.
-The city of Neverwinter serves as the origin of the phrase
"By the clocks of Neverwinter", used when one is solemly swearing, a reference to the precision of its timepieces.